Ken Murphy, M.D., Ph.D.
Eugene Opie First Centennial Professor of Pathology & Immunology
Director of Immunology Program - DBBS
Investigator, Howard Hughes Medical Institute
Pathology & Immunology
Signal Transduction/Hormone Action
Islet Biology and Immunology
Category(ies) of Research:
Descriptor of Research:
Some of the work in Dr. Murphy's lab intersects with studies on diabetes. Dr. Murphy's discovery of the Batf3 transcription factor's control of the development of the cross-presenting CD8a+ dendritic cell subset has led to analysis of the role this cell plays in several settings of infection and autoimmunity. In particular, after backcrossing the Batf3-/- mice onto the non-obese diabetic (NOD) genetic background, in collaboration with Dr. Emil Unanue, we are now finding a requirement for this subset of dendritic cell in development of the autoimmune response in NOD mice.