Diabetes Research Center (DRC)
Washington University in St. Louis

Ken Murphy, M.D., Ph.D.

Ken Murphy, M.D., Ph.D.

Eugene Opie First Centennial Professor of Pathology & Immunology
Director of Immunology Program - DBBS
Investigator, Howard Hughes Medical Institute

Pathology & Immunology

Mailing Address   Campus Box 8118
660 South Euclid Ave.
St. Louis, MO 63110
Office Location   Room 7766, 7th Floor, Clinical Sciences Research Building
Office Phone:   (314) 362-8755
Lab Phone:   (314) 362-2004
Fax:   (314) 747-4888
E-mail address:   kmurphy@pathology.wustl.edu
Assistant's E-mail address:   twalker@pathology.wustl.edu

Research Interest:

Signal Transduction/Hormone Action

Islet Biology and Immunology

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Category(ies) of Research:

Basic

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Descriptor of Research:

Some of the work in Dr. Murphy's lab intersects with studies on diabetes. Dr. Murphy's discovery of the Batf3 transcription factor's control of the development of the cross-presenting CD8a+ dendritic cell subset has led to analysis of the role this cell plays in several settings of infection and autoimmunity. In particular, after backcrossing the Batf3-/- mice onto the non-obese diabetic (NOD) genetic background, in collaboration with Dr. Emil Unanue, we are now finding a requirement for this subset of dendritic cell in development of the autoimmune response in NOD mice.

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Pathology & Immunology

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PubMed