Diabetes Research Center (DRC)
Washington University in St. Louis

Christopher J. Lingle, Ph.D.

Christopher J. Lingle, Ph.D.

Professor

Anesthesiology

Mailing Address   Campus Box 8054
660 S. Euclid Ave
St. Louis, MO 63110
Office Location   CSRB 5552-5554
Office Phone:   (314) 362-8558
Lab Phone:   (314) 362-8559
Fax:   (314) 362-8571
E-mail address:   clingle@morpheus.wustl.edu

Research Interest:

Signal Transduction/Hormone Action

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Category(ies) of Research:

Basic

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Descriptor of Research:

We are interested in the fundamental properties of large-conductance calcium-activated BK-type potassium channels, which are abundantly expressed in pancreatic beta cells. Beta cell BK channels exhibit a inactivation mediated by an auxiliary beta2 subunit. It is increasingly recognized that such BK channels are intimately coupled to Cav1.3 calcium channels and play a critical role in driving pacemaker electrical activity in many cell types, a process likely to be fundamental to regulation of insulin secretion.

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Anesthesiology Basic Rsrch Unit

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Lingle Lab

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PubMed