Diabetes Research Center (DRC)
Washington University in St. Louis

Stuart Kornfeld, M.D.

Stuart Kornfeld, M.D.

Professor of Medicine

Internal Medicine, Divisions of Hematology & Oncology

Mailing Address   660 S. Euclid Ave
Campus Box 8125
St. Louis, MO 63110
Office Location   4939 Children's Place
CSRB Room 8828
Office Phone:   (314) 362-8803
Lab Phone:   (314) 362-8828
Fax:   (314) 362-8826
E-mail address:   skornfel@dom.wustl.edu

Research Interest:

Metabolic Regulation and Obesity

Signal Transduction/Hormone Action

Islet Biology and Immunology

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Category(ies) of Research:

Basic

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Descriptor of Research:

The three homologs of the Golgi-localized, gamma-ear-containing, ADP-ribosylation factor-binding proteins (GGAs 1,2, and 3) of mammalian cells are monomeric clathrin adaptor proteins. Cell-culture based studies showed that GGAs participate in Glut 4 trafficking in insulin responsive cells. We have generated GGA1,GGA3 and GGA1/3 null mice in a mixed background and are backcrossing them into the C57bl background for use in studies of glucose tolerance, insulin responsiveness, glut4 trafficking and adipocyte function. The GGA2 KO is neonatal lethal, so can’t be used for these types of studies.

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Hematology & Oncology

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PubMed