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Overview
There are 20 DRTC members including 3 new members who are funded to study various aspects
of signal transduction &/or hormone action as it relates to metabolism and diabetes. These studies are
being conducted in experimental animal and cell culture models.
Irving Boime, PhD
Molecular Biology & Pharmacology
314-362-2556
Research Interest: Regulation and structure of the human placental hormone genes
during development
iboime@wustl.edu
Alex J. Brown, PhD
Medicine/Renal Research
314-362-2556
Research Interest: Activation of vitamin D
abrown22@wustl.edu
Kyunghee Choi, PhD
Pathology & Immunology
314-362-8716
Research Interest: The program utilizes an in vitro differentiation model of embryonic
stem (ES) cells and early mouse embryos to study the mechanisms by which blood and blood vessel
cell lineage differentiation are regulated
kchoi@wustl.edu
Simon Fisher, MD, PhD
Medicine/Endocrinology
314-362-3268
Research Interest: identify the systemic regulators of blood sugar levels
associated with insulin action in the central nervous system
sfisher22@wustl.edu
Phyllis I. Hanson, MD, PhD
Cell Biology & Physiology
314-747-4233
Research Interest: understanding the regulation of intracellular membrane trafficking
by a family of chaperone-like ATPases known as AAA+ proteins
phanson22@wustl.edu
Paul W. Hruz, MD, PhD
Pediatric Endocrinology & Diabetes
314-286-2797
Research Interest: intermediary carbohydrate metabolism, glucose transporter structure and function, mechanism of insulin action, and the
molecular mechanisms leading to congenital and acquired lipodystrophies
hruzp@wustl.edu
Douglas Lublin, MD, PhD
Pathology & Immunology
314-362-8849
Research Interest: cholesterol-rich domains of the plasma membrane termed lipid rafts and caveolae
lublin@wustl.edu
Veronica Luzzi, PhD
Medicine/Endocrinology
314-362-3516
Research Interest: Immunoassay Core labs
vluzzi@wustl.edu
Robert W. Mercer, PhD
Cell Biology & Physiology
314-362-6924
Research Interest: using the methods of molecular biology to study the structure, function,
and regulation of the Na,K-ATPase enzyme
rmercer@wustl.edu
Jeffrey F. Moley, MD,
Surgery (General Surgery)
314-367-0064
Research Interest: Expression of glucose transporters in colon cancer, sarcomas, and endocrine
tumors
moleyj@wustl.edu
Mike Mueckler, PhD
Cell Biology & Physiology
314-362-4160
Research Interest: study the structure, biosynthesis, and regulation
of the mammalian facilitated-diffusion glucose transporters (GT)
mike@cellbio.wustl.edu
Louis J. Muglia, MD, PhD
Pediatrics/Endocrinology & Diabetes
314-286-2847
Research Interest: defining the role of neuropeptides produced by the hypothalamus in
perinatal adaptation, reproduction, behavior, and immune function
muglia_l@wustl.edu
Anthony J. Muslin, MD
Medicine/Cardiology
314-747-3525
Research Interest: The molecular causes of cardiac hypertrophy and congestive heart failure
amuslin@wustl.edu
Alan L. Schwartz, PhD, MD
Pediatrics/Hematology & Oncology
314-454-6005
Research Interest: the cell and molecular biology of intracellular protein
targeting and degradation
schwartz@wustl.edu
Andrey S. Shaw, MD
Pathology & Immunology
314-362-4614
Research Interest: the field of signal transduction
ashaw@wustl.edu
Philip D. Stahl, PhD
Cell Biology & Physiology
314-362-6950
Research Interest: the role of signal transduction in membrane trafficking
pstahl@wustl.edu
Thomas H. Steinberg, MD
Medicine/Infectious Diseases
314-362-9218
Research Interest: the main focus has evolved to encompass several areas related
to intercellular communication
steinber@wustl.edu
Dwight Towler, MD, PhD
Medicine/Bone & Mineral Diseases
314-454-7434
Research Interest: Identification and characterization of osteoblast transcription factors
dtowler@wustl.edu
Burton Wice, PhD
Medicine/Endocrinology
314-747-0423
Research Interest: Understanding the molecular mechanisms that
regulate insulin production and secretion by islet b -cells
bwice@wustl.edu
David B.Wilson, MD, PhD
Pediatrics/Developmental Biology & Genetics
314-286-2834
Research Interest: The role of transcription factors in differentiation and development
wilson_d@wustl.edu
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