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Overview
There are 26 DRTC members who are funded to study various aspects of metabolic
regulation and/or obesity. Fifteen members are primarily focusing in this area and are described
in this section, while 11 are included in more than one research group and are described either in
Clinical and Translational Research, Complications, Signal Transduction, or
Islet Biology & Immunology. These studies are being conducted in experimental animals and
in humans, both in vivo and ex vivo, evaluating metabolic regulation in skeletal muscle, liver, and
adipose tissue. Seven of these 26 members are new to the DRTC since 2002, and 3 of these new members
are young Provisional Members in the early phases of their careers.
Collaboration/Interactions. Many investigators in this area are active participants in the weekly
Endocrinology & Metabolism and Nutrition seminar series. Moreover, an extensive network of
collaborations among investigators within the metabolism area and with the complications area
facilitates the progress of scientific discovery in our DRTC.
Nada A. Abumrad, PhD
Medicine/Nutritional Science
314-747-0348
Research Interest: Molecular mechanisms regulating utilization of fatty acids
nabumrad@wustl.edu
Carlos Bernal-Mizrachi, MD
Medicine/Endocrinology
314-362-0947
Research Interest: Type 2 diabetes mellitus, obesity, hypertension and coronary artery disease
cbernal@wustl.edu
Perry E. Bickel, MD
Medicine/Endocrinology
314-362-7641
Research Interest: Type 2 diabetes mellitus, obesity, hypertension and coronary artery disease
pbickel@wustl.edu
Manu V. Chakravarthy, MD
Medicine/Endocrinology
314-362-4453
Research Interest: diabetes research
mchakrav@wustl.edu
James M. Cheverud, PhD
Anatomy & Neurobiology
314-362-4188
Research Interest: evolutionary quantitative genetics and morphology
cheverud@wustl.edu
Nicholas O. Davidson, MD
Medicine/Gastroenterology
314-362-2027
Research Interest: complex lipid trafficking from cells of the small intestine and liver
nod@wustl.edu
Brian Finck, PhD
Medicine/Nutritional Science
314-362-8963
Research Interest: the molecular control of fatty acid metabolism
bfinck@wustl.edu
Jeffrey I Gordon, MD
Center for Genome Sciences
314-362-7243
Research Interest: The genomic and metabolic foundations of our mutually beneficial
relationships with microbes
jgordon@.wustl.edu
Richard W. Gross, MD, PhD
Chemistry
314-362-2690
Research Interest: The chemical biology of membranes in health and disease
rgross@wustl.edu
John O. Holloszy, MD
Medicine/Applied Physiology
314-362-3506
Research Interest: Hormone Action & Membrane Transport
jhollosz@im.wustl.edu
Daniel P. Kelly, MD
Medicine/Cardiology
314-747-3032
Research Interest: The regulatory mechanisms related to the control of cardiac
energy metabolism in the developing and diseased heart
dkelly@wustl.edu
Samuel Klein, MD
Medicine/Nutritional Science
314-362-8708
Research Interest: Pathophysiology of Lipid Metabolism in Obesity
sklein@wustl.edu
Ellen Li, MD, PhD
Medicine/Gastroenterology
314-362-8940
Research Interest: To understand the structure and function of vitamin A binding proteins
eli@wustl.edu
Bettina Mittendorfer, PhD
Medicine/Nutritional Science
314-362-8450
Research Interest: The use of stable isotope labeled tracers for the investigation
of metabolism in vivo
mittenb@wustl.edu
Kelle H. Moley, MD
Obstetrics & Gynecology
314-362-1765
Research Interest: How early pre-implantation glucose transport and metabolism affect
the fate and outcome of pregnancy at a molecular level
moleyk@wustl.edu
Kristin E. Mondy, MD
Medicine/Infectious Diseases
314-289-6433
Research Interest: HIV-related metabolic complications
kmondy@wustl.edu
Daniel S. Ory, MD
Medicine/Cardiology
314-362-8737
Research Interest: In atherosclerosis circulating monocytes migrate into the subendothelial space overlying nascent lesions,
where they differentiate into macrophages, and take up atherogenic plasma lipoproteins
dory@wustl.edu
Richard E. Ostlund, Jr. MD
Medicine/Endocrinology
314-362-8286
Research Interest: This research studies why cholesterol
absorption differs between subjects and to relate differences to physiological mechanisms
rostlund@wustl.edu
Dominic N. Reeds, MD
Medicine/Nutritional Science
314-362-8430
Research Interest: Changes in glucose and lipid metabolism during weight gain or loss
dreeds22@wustl.edu
Jean E. Schaffer, MD
Medicine/Cardiology
314-362-8717
Research Interest: The work is to understand the molecular mechanisms
of plasma membrane fatty acid transport and channeling of these lipids to specific metabolic fates
jschaff@wustl.edu
Gustav Schonfeld, MD
Medicine/Endocrinology
314-362-8060
Research Interest: The genetic etiology and metabolism of familial hypobeta-lipoproteinemia in human populations
and families and in mouse models
gschonfe@wustl.edu
Clay F. Semenkovich, MD
Medicine/Endocrinology
314-362-4454
Research Interest: Lipid metabolism and how it promotes atherosclerosis in people with diabetes
csemenko@wustl.edu
Dwight Towler, MD, PhD
Medicine/Bone & Mineral Diseases
314-454-7434
Research Interest: Identification and characterization
of osteoblast transcription factors
dtowler@wustl.edu
John W. Turk MD, PhD
Medicine/Endocrinology
314-362-8190
Research Interest: Regulation of insulin secretion from pancreatic islets
jturk@wustl.edu
Dennis T. Villareal, MD
Medicine/Nutritional Science
314-286-2715
Research Interest: preventing frailty in obese and non-obese older adults
dvillare@wustl.edu
Michael J. Welch, PhD
Radiology & Chemistry
314-362-8436
Research Interest: Positron emission tomography (PET)
welchm@wustl.edu
Kevin Yarasheski, PhD
Medicine/Endocrinology
314-362-8173
Research Interest: Pathogenesis & treatments for metabolic,
anthropomorphic & cardiovascular syndromes
key@wustl.edu
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