|
Overview
This group is comprised of 25 investigators that include 9 new members
of which 5 are newly appointed faculty. This group is evaluating islet development, proliferation
and survival in models of immune type 1 diabetes (T1DM), function in glucose and lipid conditions
that characterize T2DM, and in islet transplantation in experimental animal models and in patients with T1DM. There is a
particularly strong interest in how failure of the immune system to tolerate self-antigens results
in autoimmune destruction of islet beta cells in T1DM.
Collaborations/Interactions
The DRTC provides a rich environment for islet biology research in
which reagents, animal models and experimental protocols are shared and in which there are many
productive collaborations, as outlined above. The DRTC has also coordinated a weekly Beta Cell Biology
Lab Report and Journal Club in which the Polonsky, Permutt, McDaniels, Bernal-Mizrachi, Turk, Corbett,
Unanue, Suri, Levisetti, and Nichols labs present work-in-progress or relevant journal articles.
Critical appraisal of ongoing work helps prepare trainees for national presentations and manuscript
and grant writing.
Paul M. Allen, PhD
Pathology & Immunology
314-362-8758
Research Interest: T-cells
pallen@wustl.edu
Ernesto Bernal-Mizrachi, MD
Medicine/Endocrinology
314-362-8758
Research Interest: study of the physiology and the role of pancreatic b-cells
in the pathogenesis of type 2 diabetes
ebernal@wustl.edu
Bernal-Mizrachi Lab Website
John A. Corbett, PhD
SLU/Biochemistry & Molecular Biology
314-362-2693
Research Interest: selective destruction of pancreatic b-cells
corbettj@slu.edu
Marc R. Hammerman, MD
Medicine/Renal research
314-362-8232
Research Interest: exploring the possibility that organ primordia (kidneys or pancreas) can be transplanted
in 'cellular' form so that they develop in situ and become vascularized by the host
mhammerm@wustl.edu
Shin-Ichiro Imai, MD, PhD
Molecular Biology & Pharmacology
314-362-7228
Research Interest: The molecular mechanism of mammalian aging and longevity
imaishin@wustl.edu
Raphael Kopan, PhD
Molecular Biology & Pharmacology
314-747-5520
Research Interest: A central process in the development of multicellular organisms is the generation
of different cell types
kopan@wustl.edu
Joseph C. Koster, PhD
Cell Biology & Physiology
314-362-6922
Research Interest: Developing additional mouse models of KATP-induced diabetes
with the expectation that less ‘overactive’ KATP channel activity will result in a
milder and later-onset diabetic phenotype
jkoster@wustl.edu
Matteo G. Levisetti, MD
Medicine/Endocrinology
314-362-1265
Research Interest: The work in my laboratory focuses on the molecular mechanisms
that lead to the autoimmune destruction of the insulin producing beta-cells of the pancreas
mleviset@wustl.edu
Christopher J. Lingle, MD
Anesthesiology
314-362-8558
Research Interest: Functional properties and physiological roles of Ca2+- and
voltage-dependent K+ channels
clingle@wustl.edu
Michael L. McDaniel, PhD
Pathology & Immunology
314-362-7435
Research Interest: The focus of this laboratory is to study the function and growth of pancreatic
islets in types 1&2 diabetes
mmcdaniel@wustl.edu
Jason C. Mills, MD, PhD
Pathology & Immunology
314-362-4213
Research Interest: The focus of this laboratory is to study the function and growth of pancreatic
islets in types 1&2 diabetes
jmills@wustl.edu
Thalachallour Mohanakumar, PhD
Surgery
314-362-8463
Research Interest: Immunology
kumart@wustl.edu
Jeanne M. Nerbonne, PhD
Molecular Biology & Pharmacology
314-362-2564
Research Interest: Delineating the mechanisms involved in the regulation and
modulation of voltage-gated ion channels in cardiac myocytes and cortical neurons
jnerbonne@wustl.edu
Colin G. Nichols, PhD
Cell Biology & Physiology
314-362-6630
Research Interest: Our research is focused on the molecular and cellular regulation of potassium
channels, and their role in linking cellular metabolism to electrical activity in various tissues
cnichols@wustl.edu
M. Alan Permutt, MD
Medicine/Endocrinology
314-362-8283
Research Interest: Genetics & Islet Biology
apermutt@wustl.edu
Kenneth S. Polonsky, MD
Medicine/Endocrinology
314-362-1296
Research Interest: The role of the b-cell in the pathophysiology of non-insulin
dependent diabetes mellitus (NIDDM)
polonsky@wustl.edu
Sasanka Ramanadham, PhD
Medicine/Endocrinology
314-362-8194
Research Interest: islet research
sramanad@wustl.edu
Robert D. Schreiber, PhD
Pathology & Immunology
314-362-8747
Research Interest: Our research is aimed at elucidating the molecular cell biology of cytokine
receptor signaling and in defining the effects of signaling dysfunction on tumor development
schreiber@wustl.edu
Anish Suri, PhD
Pathology & Immunology
314-362-7526
Research Interest: Our research is aimed at elucidating the molecular cell biology of cytokine
receptor signaling and in defining the effects of signaling dysfunction on tumor development
asuri@wustl.edu
John W. Turk MD, PhD
Medicine/Endocrinology
314-362-8190
Research Interest: Regulation of insulin secretion from pancreatic islets
jturk@wustl.edu
Emil R. Unanue, MD
Pathology & Immunology
314-362-7440
Research Interest: To understand how protein antigens are recognized by T lymphocytes following
their uptake by antigen presenting cells (APC)
unanue@wustl.edu
Herbert W. Virgin, MD, PhD
Pathology & Immunology
314-362-9223
Research Interest: the interface between virology and immunology
virgin@wustl.edu
Burton Wice, PhD
Medicine/Endocrinology
314-747-0423
Research Interest: Understanding the molecular mechanisms that
regulate insulin production and secretion by islet b -cells
bwice@wustl.edu
Xiaoming Xia, PhD
Anesthesiology
314-747-4178
Research Interest: the protein interactions that involve membrane proteins, specifically receptors
and channels
xiax@wustl.edu
|
