Diabetic Complications Component

Overview

Among investigators affiliated with the DRTC, 33 are funded in the area of diabetes complications. Major areas of focus include:

• cardiovascular disease
• neuropathy and CNS complications
• renal complications
• ocular complications
• wound and bone complications
• reproduction
• cellular mechanisms of complications.

These investigations in the area of complications include basic molecular cell biology to translational studies in mouse models to clinical studies in diabetes patients. Of these investigators 8 are new to the DRTC since 2002 and 4 are young investigators who are early in their careers and new to the field of diabetes. Below we highlight the investigators who are primarily focused on complications.

Dana R. Abendschein, PhD Medicine/Cardiology 314-362-8925 Research Interest: Molecular responses of the arterial wall and heart to injury dabendsc@wustl.edu Rajendra S. Apte, MD,PhD Ophthalmology & Visual Sciences 314-747-5262 Research Interest: Diseases of the retina apte@wustl.edu Jeffrey M. Arbeit, MD Surgery/Urology 314-362-3222 Research Interest: Discovering novel mechanisms regulating epithelial cancer development arbeitj@wustl.edu Thomas J. Baranski, MD, PhD Medicine/Endocrinology 314-362-7054 Research Interest: Protein-protein interactions govern the specificity of molecular communication baranski@wustl.edu David C. Beebe, PhD Ophthalmology & Visual Sciences 314-362-1621 Research Interest: Molecular and cellular biology of eye development ; mechanism of nuclear cataract formation beebe@wustl.edu Daniel C. Brennan, MD Medicine/Renal Transplantation 314-362-8351 Research Interest: Transplant nephrology dbrennan@wustl.edu W. Todd Cade, PT, PhD Program in Physicial Therapy 314-286-1432 Research Interest: Mechanisms and treatments (nutritional/exercise/pharmaceutical) for whole body tcade@wustl.edu Sharon Cresci, MD Medicine/Center for Cardiovascular Research 314-362-9926 Research Interest: The association of genetic variation with clinical outcomes in patients with cardiovascular disease and on the role of genetic variation in the variable response to pharmacologic treatment of cardiovascular disease scresci@wustl.edu Philip E. Cryer, MD Medicine/Endocrinology 314-362-7635 Research Interest: Hypoglycemia & Diabetes pcryer@wustl.edu Robert J. Gropler, MD Radiology/Nuclear Medicine 314-747-3878 Research Interest: Nuclear medicine, coronary artery disease groplerr@wustl.edu Tamara Hershey, PhD Psychiatry 314-362-5593 Research Interest: The neural underpinnings of cognitive dysfunction in several diseases relevant to dopamine and/or development tammy@wustl.edu Keith A. Hruska, MD Pediatrics/Nephrology 314-286-2855 Research Interest: The mechanisms of chronic kidney disease (CKD), and its complications hruska_k@wustl.edu Daniel P. Kelly, MD Medicine/Cardiology 314-747-3032 Research Interest: The regulatory mechanisms related to the control of cardiac energy metabolism in the developing and diseased heart dkelly@wustl.edu Samuel Klein, MD Medicine/Nutritional Science 314-362-8708 Research Interest: Pathophysiology of Lipid Metabolism in Obesity sklein@wustl.edu John J. Lehman, MD Medicine/Cardiology 314-362-8912 Research Interest: diabetic complications jlehman@wustl.edu Janet McGill, MD Medicine/Endocrinology 314-362-8681 Research Interest: Clinical Research & Genetics jmcgill@wustl.edu Kelle H. Moley, MD Obstetrics & Gynecology 314-362-1765 Research Interest: How early pre-implantation glucose transport and metabolism affect the fate and outcome of pregnancy at a molecular level moleyk@wustl.edu Kristin E. Mondy, MD Medicine/Infectious Diseases 314-289-6433 Research Interest: HIV-related metabolic complications kmondy@wustl.edu Michael J. Mueller, PT, PhD FAPTA Program in Physicial Therapy 314-286-1428 Research Interest: Director of the Applied Biomechanics Laboratoy which studies the biomechanical factors that contribute to injury and adaptation in patients with chronic disabilities muellerm@wustl.edu Anthony J. Muslin, MD Medicine/Cardiology 314-747-3525 Research Interest: The molecular causes of cardiac hypertrophy and congestive heart failure amuslin@wustl.edu Jeanne M. Nerbonne, PhD Molecular Biology & Pharmacology 314-362-2564 Research Interest: Delineating the mechanisms involved in the regulation and modulation of voltage-gated ion channels in cardiac myocytes and cortical neurons jnerbonne@wustl.edu John W. Newcomer, MD Psychiatry 314-362-5939 Research Interests: 1)metabolic and cardiovascular risk factors in individuals with neuropsychiatric disorders; 2) metabolic effects of antipsychotics in children; 3) neurochemical regulation of memory performance in humans; 4) therapies for neuropsychiatric disorders, particularly psychotic disorders newcomerj@wustl.edu Margaret A. Perkinson PhD Program in Occupational Therapy/Anthropology 314-935-6221 Research Interest: Caregiving Processes and the Elderly maperkin@wustl.edu J. Mark Petrash, PhD Ophthalmology & Visual Sciences 314-362-3335 Research Interest: Structure and function of the aldo-keto reductase (AKR) enzyme family petrash@wustl.edu Joan K. Riley, PhD Obstetrics & Gynecology 314-362-1997 Research Interest: The work is to understand the molecular mechanisms of plasma membrane fatty acid transport and channeling of these lipids to specific metabolic fates rileyj@wustl.edu Jean E. Schaffer, MD Medicine/Cardiology 314-362-8717 Research Interest: The work is to understand the molecular mechanisms of plasma membrane fatty acid transport and channeling of these lipids to specific metabolic fates jschaff@wustl.edu Robert E. Schmidt, MD, PhD Pathology & Immunology 314-362-7429 Research Interest: The determination of the mechanisms underlying the response of the peripheral nervous system to various forms of toxic, immunologic, age-related and metabolic injury reschmidt@wustl.edu Clay F. Semenkovich, MD Medicine/Endocrinology 314-362-4454 Research Interest: Lipid metabolism and how it promotes atherosclerosis in people with diabetes csemenko@wustl.edu Yvette I. Sheline, MD Psychiatry/Pain Center 314-362-2586 Research Interest: Depression & pain disorders yvette@wustl.edu Matthew J. Silva, PhD Orthopaedic Surgery 314-362-8585 Research Interest: The biomechanics of age-related fractures and osteoporosis silvam@wustl.edu David R. Sinacore, PT, PhD FAPTA Program in Physicial Therapy 314-286-1423 Research Interest: Director of the Applied Kinesiology Laboratory; Diabetic foot disease and prevention of LEA sinacored@wustl.edu R. Reid Townsend, MD, PhD Medicine/Endocrinology 314-362-7709 Research Interest: Proteomics, which is the study of the range of proteins and protein interactions in healthy and diseased cells rtownsend@wustl.edu John W. Turk MD, PhD Medicine/Endocrinology 314-362-8190 Research Interest: Regulation of insulin secretion from pancreatic islets jturk@wustl.edu Michael J. Welch, PhD Radiology & Chemistry 314-362-8436 Research Interest: Positron emission tomography (PET) welchm@wustl.edu Kathryn A. Yamada, PhD Medicine/Cardiology 314-362-8909 Research Interest: cellular electrophysiologic mechanisms that lead to ventricular arrhythmias a nd sudden cardiac death during myocardial ischemia, infarction, hypertrophy, and failure kyamada@wustl.edu Kevin Yarasheski, PhD Medicine/Endocrinology 314-362-8173 Research Interest: Pathogenesis & treatments for metabolic, anthropomorphic & cardiovascular syndromes key@wustl.edu